P3.01-023 First-line Afatinib for Non-Small Cell Lung Cancer in Real World Practice
نویسندگان
چکیده
منابع مشابه
Afatinib treatment in advanced non-small cell lung cancer.
Despite some recent advances in the management of advanced non-small cell lung cancer (NSCLC), prognosis for these patients remains poor. Small molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have however provided a new therapeutic option in this disease setting and EGFR mutation testing is now routine practice for newly diagnosed NSCLC patients. A proportion ...
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We read with great interest the article by Pirazzoli and colleagues on the ability of afatinib and cetuximab (AC) combination to delay resistance compared with afatinib alone (A) in a mouse model of EGFR-mutant lung adenocarcinoma (1). The main mechanism of resistance to AC in animals was the T790M mutation. It was detected in the same proportion than observed in human tumors that became resist...
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Pemetrexed is a new cytotoxic agent that is a standard of care for the second-line treatment of non-small cell lung cancer (NSCLC) and in combination with cisplatin in treatment of malignat pleural mesothelioma. It has been studied in numerous phase II and III trials in combination with different drugs or as single agent. Recently, pemetrexed has been approved in combination with cisplatin for ...
متن کاملReal-world practice patterns for patients with advanced non-small cell lung cancer: multicenter retrospective cohort study in Japan
Background Recommended therapies for advanced/metastatic non-small cell lung cancer (NSCLC) have changed with the advent of targeted therapies. The objectives of this retrospective chart review study were to describe treatment patterns, biomarker testing practices, and health care resource use for advanced NSCLC at 5 sites in Japan. Patients and methods We studied anonymized medical record da...
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AIM Cytotoxic chemotherapy is the standard first-line therapy for patients with advanced non-small cell lung cancer (NSCLC) without specific gene alterations. This study examined the prescription pattern and the survival outcome of cytotoxic chemotherapy regimens in daily practice in Taiwan. METHODS We established a population-based cohort of patients diagnosed with advanced NSCLC between 200...
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2017.09.1464